HYPONATREMIA AND SEIZURES FOLLOWING THE ADMINISTRATION OF DDAVP FOR NOCTURNAL ENURESIS

Key words: Desmopressin (DDAVP), Hyponatremia, Seizures, Nocturnal Enuresis

Desmopressin (DDAVP) is widely used in the treatment of primary nocturnal enuresis. It is a safe and effectiv drug, but occasionally water intoxication may occur. We report a 5 - year - old girl who developed generalized seizures due to hyponatremia, after a single therapeutic dose of intranasal DDAVP for enuresis. Guidelines are given to avoid the risk of water intoxication following the DDAVP administration: to exclude from treatment very young children, to control water intake before bed time and to control weight at morning time.