Dicembre 2007 - Volume XXVI - numero 10
Focus
Key words: Pneumatic nebulizer, Ultrasonic nebulizer, Metered-dose inhaler (MDI), Dry powder inhaler
The percentage of a prescribed drug that is able to reach the lung (delivery power) is low and varies widely when both nebulizers, pneumatic and ultrasonic, are used. The Metered- Doser Inhaler (MDI) has a higher and more constant efficiency, moreover when associated to a spacer provided with valves, it zeroes the ballistic effect (the impact of the drug with the oropharynx) and makes the procedure suitable for all ages. Conversely, Dry Powder Inhaler enhances the ballistic effect and requires a much higher patient collaboration. Independently from the technique used, the percentage of drug that actually reaches the lung in the child is much lower than that in adult (2-6% versus 16-20%): hence the necessity to reconsider the dosages via inhalation for paediatric use. In order to get the best collaboration on behalf of the parents it is mandatory that they are instructed on the basics of inhalation therapy and shown the correct procedure.
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