Novembre 2000 - Volume XIX - numero 9

Medico e Bambino


Pagina verde

Prevenire il diabete con dieta senza glutine anche nei non celiaci? risultati preliminari

A. Tommasini, E. Neri, E. Zamuner, G. Torre, T. Not, A. Ventura

Clinica Pediatrica, Università di Trieste e IRCCS “Burlo Garofolo”, Trieste

Anti-pancreas antibodies (ICA, GAD, IAA) identifie high-risk relatives of diabetics subject. On the other hand, foods and infections have been considered environmental factors relevant to the risk of IDD. Moreover, in coeliac patients anti-islet positive, gluten-free diet reverse that condition. We investigated the hystology of gut mucosa in 8 anti-islet positive, EMA negative, anti-tTG negative, IDDM relatives and the effect of a gluten free diet on the intestinal hystology and on the anti-islet antibodies. In 5 patients mucosal lesions of coeliac type (Marsh 3 to 3c degree) have been found. In 3 of 5 who mantained a gluten-free diet for a year, mucosal lesions and anti-islet antibodies cleared. That suggest a non-specific adjuvant effect of gliadine on the intestinal lesions and on the anti-insula autoimmunity, also non-coeliac patients.

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A. Tommasini, E. Neri, E. Zamuner, G. Torre, T. Not, A. Ventura Prevenire il diabete con dieta senza glutine anche nei non celiaci? risultati preliminari. Medico e Bambino 2000;19(9):599 https://www.medicoebambino.com/?id=0009_599.pdf


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