Crohn’s disease is an inflammatory bowel disease diagnosed in paediatric age, especially during adolescence, in approximately one third of the cases. Pathogenesis is unknown but growing evidence suggests that immunological anomalies due to monogenic or more frequently polygenic multifactorial alterations play a pivotal role. Classic symptoms such as abdominal pain, diarrhoea and blood in stools may be absent while systemic non-abdominal disturbances like fatigue, poor growth, anaemia and intestinal complication requiring surgery may be the first manifestation of the disease. Through the described three cases, the paper proposes some synthetic summaries on the presentation, the pathogenesis and the therapy of Crohn’s disease in children.
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