Dalla dermatite atopica all’asma: possibilità di prevenzione farmacologica
FERNANDO M. DE BENEDICTIS1*, ATTILIO BONER2*, LUISA BUSINCO3*, PAOLO MEGLIO3*, GIOVANNI CAVAGNI4*, ALESSANDRO FIOCCHI5*, MASSIMO MASI6*
1Clinica Pediatrica dell’Università di Perugia, 2Clinica Pediatrica dell’Università di Verona 3Clinica Pediatrica dell’Università di Roma 4Clinica Pediatrica dell’Università di Brescia 5Clinica Pediatrica dell’Università di Milano 6Clinica Pediatrica dell’Università di Bologna *ETAC Italian Study Group
FROM ATOPIC DERMATITIS TO ASTHMA: EVALUATION OF EARLY TREATMENT WITH CETIRIZINE
A multicentre study was carried out to evaluate the efficacy of early treatment with cetirizine
of children affected by atopic dermatitis. 817 patients aged 12 to 24 months and affected
by atopic dermatitis were randomized to receive either cetirizine (0.25 mg/kg twice a
day) or placebo for 18 months. Total and specific IgE levels as well as physical examination
were performed throughout the study period. Sensitivity to house mite and cat but also
to pollen were shown to be highly predictive of the risk of subsequent development of asthma.
There were no significant differences between cetirizine and placebo groups with respect
to the development of asthma but in the subgroup of patients with high baseline IgE
for pollen and house dust mite treatment with cetirizine was associated with lower incidence
of asthma. These results cannot be considered conclusive until the data on longer followup
will be available.