Unità Operativa di Pediatria, Ospedale Maggiore “C.A. Pizzardi”, Bologna
Key words: Desmopressin (DDAVP), Hyponatremia, Seizures, Nocturnal Enuresis
Desmopressin (DDAVP) is widely used in the treatment of primary nocturnal enuresis. It is a safe and effectiv drug, but occasionally water intoxication may occur. We report a 5 - year - old girl who developed generalized seizures due to hyponatremia, after a single therapeutic dose of intranasal DDAVP for enuresis. Guidelines are given to avoid the risk of water intoxication following the DDAVP administration: to exclude from treatment very young children, to control water intake before bed time and to control weight at morning time.
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