Ottobre 2020 - Volume XXXIX - numero 8

Medico e Bambino


Percorsi clinici

Febbre di origine sconosciuta (FUO): approccio diagnostico attraverso un caso clinico

Davide Ursi, Simona Puzone, Caterina Strisciuglio

Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università della Campania “Luigi Vanvitelli”

Indirizzo per corrispondenza: ursi.davide@gmail.com

Fever of unknown origin: Diagnostic approach through a clinical case

Key words: FUO, Cytomegalovirus, Ulcerative colitis, Fever, Rash

The paper reports the case of a 12-year-old female affected by ulcerative colitis and treated with double immunosuppressant therapy (methotrexate and infliximab). The patient presented with 7 day-lasting fever associated with pharyngotonsillar hyperaemia, cheilitis, vesicular-bollous lesions on labial mucosa and rash on malar regions, chest and upper extremities. Since full blood count showed lymphocytosis and inflammatory markers were negative, a viral infection was suspected. Virological tests identified the presence of IgM against Cytomegalovirus (CMV), Herpes and Mumps viruses, but Real-Time PCR was negative for the DNA detection of any of those viruses. Despite hospital admission and different investigations, fever persisted for more than 7 days without any explanation. Therefore, it was considered as Fever of unknown origin (FUO). FUO is often an unusual manifestation of a common disease but so far there is not a single validated diagnostic protocol. In the presented case only did the repetition of the Real-Time PCR test after a few days enable CMV DNA to be identified in the patient’s blood and urine and CMV infection to be diagnosed.

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D. Ursi, S. Puzone, C. Strisciuglio Febbre di origine sconosciuta (FUO): approccio diagnostico attraverso un caso clinico . Medico e Bambino 2020;39(8):519-525 https://www.medicoebambino.com/?id=2008_519.pdf


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