Febbraio 2018 - Volume XXXVII - numero 2

Medico e Bambino


Pagine elettroniche

Cos'è la sindrome di Jeune e quando pensarci
Descrizione di un caso clinico

Beatrice Vergara1, Claudia Muratori1, Lorenzo Mambelli1, Andrea Zucchini1, Rosita Iannace2, Giulia Parmeggiani3, Alberto Sensi3, Federico Marchetti1

1UOC di Pediatria e Neonatologia, Ospedale di Ravenna, AUSL della Romagna
2Pediatra di famiglia, Faenza
3UO di Genetica Medica, Laboratorio Unico della Romagna, Pievesestina (Cesena), AUSL della Romagna

Indirizzo per corrispondenza: federico.marchetti@auslromagna.it

What is Jeune syndrome and when paediatricians should think about it

Key words: Asphyxiating thoracic dystrophy, Skeletal dysplasia, Respiratory symptoms

Jeune syndrome, also known as asphyxiating thoracic dystrophy, is a rare autosomal recessive skeletal dysplasia characterised by narrow chest, short skull and skeletal abnormalities, which include, among other things, a “trident” appearance of the acetabulum and alterations metaphyseal. The narrow chest can cause neonatal respiratory failure and may be associated with persistent respiratory symptoms. Some cases are severe, while others have a benign evolution. The rate of growth is variable, but it can also be normal. Renal and hepatic failures (hepatic or nephrophytic fibrosis) have been described with variable onset. Pigmented retinal degeneration has also been observed. Cognitive development is normal. The paper describes the case of a now 18-month-old girl with typical radiologic features. She had respiratory problems during the first 12 months of life, with progressive gradual improvement. Laboratory evaluation has documented an early hepatic involvement. The treatment with ursodeoxycholic acid was beneficial and reversed enzyme levels.

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B. Vergara, C. Muratori, L. Mambelli, A. Zucchini, R. Iannace, G. Parmeggiani, A. Sensi, F. Marchetti
Cos'è la sindrome di Jeune e quando pensarci; Descrizione di un caso clinico
Medico e Bambino 2018;37(2):119-122 https://www.medicoebambino.com/?id=1802_119.pdf

Pagine elettroniche

Anticorpi anti-istone: è sempre lupus indotto da farmaci?

Annachiara Azzali, Teresa Giani, Gabriele Simonini, Rolando Cimaz

SODc Reumatologia, AOU Anna Meyer, Firenze

Indirizzo per corrispondenza: azzali.annachiara@gmail.com

Anti-histone antibodies: does it always mean drug-induced lupus erythematosus?

Key words: Systemic lupus erythematosus, Drug-induced lupus erythematosus, Antiepileptic drugs

The paper describes the case of a South-American 14-year-old girl who presented with arthralgia, weakness and alopecia. As she was under antiepileptic treatment since she was 5 years of age, on suspicion of drug-induced lupus erythematosus (DILE) anti-histone antibodies were dosed and showed positive results. She presented with mild anaemia, leukopenia, hypocomplementemia, ANA, anti-dsDNA and LAC positivity. The antiepileptic therapy was initially modified and then, as no more crises were present, interrupted. Anyway, as a minor symptomatology, anaemia, leukopenia, hypocomplementemia, ANA and anti-dsDNA persisted, the diagnosis of idiopathic systemic lupus erythematosus (SLE) was made. After treatment with hydroxychloroquine and low dose prednisone the girl clinically improved and her laboratory data normalised. This case report is suggestive of the complexity in differentiating SLE and DILE and underlines the importance of a long and careful follow-up.

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A. Azzali, T. Giani, G. Simonini, R. Cimaz
Anticorpi anti-istone: è sempre lupus indotto da farmaci?
Medico e Bambino 2018;37(2):119-122 https://www.medicoebambino.com/?id=1802_119.pdf

Pagine elettroniche

Glomerulopatia da depositi di C3

Stefano Amoroso1, Marco Pennesi2, Alessandro Ventura1,2

1Università di Trieste
2IRCCS Materno-Infantile “Burlo Garofolo”, Trieste

Indirizzo per corrispondenza: stefanoamoroso1234@gmail.com

C3-glomerulopathy - What should paediatricians know

Key words: C3-glomerulopathy, Hypocomplementemia, Membranoproliferative glomerulonephritis, Mofetil micofenolate, Eculizumab

C3-glomerulopathy includes several nephropathy charac-terised by almost only C3 deposits without immunoglobu-lins with a mesangial proliferative or membrano-proliferative pattern on light microscopy. C3-glomerulopathy is determined by a dysregulation of the al-ternative pattern of complement due to autoantibodies such as C3 nephritic factor or mutations of complement pro-teins. Corticosteroids combined with mofetil micofenolate could be effective in inducing a partial or complete remis-sion. Eculizumab, the humanised monoclonal antibody di-rected against C5, has been shown to have a favourable effect in several case series of patients.

Vuoi citare questo contributo?

S. Amoroso, M. Pennesi, A. Ventura
Glomerulopatia da depositi di C3
Medico e Bambino 2018;37(2):119-122 https://www.medicoebambino.com/?id=1802_119.pdf


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