Dicembre 2012 - Volume XXXI - numero 10

Medico e Bambino


Farmacoriflessioni

I corticosteroidi nelle malattie respiratorie: certezze e dubbi 60 anni dopo (Seconda parte)

Fernando Maria De Benedictis1, Fabrizio Franceschini1, Roberto Budassi2, Alessandro Capolongo2, Costantino Gobbi2, Arcangela Guerrieri2, Cesare Migliori2, Anna Nobilini2, Claudia Pasqualini1

1SOD Pediatria, Azienda Ospedaliero-Universitaria “Ospedali Riuniti”, Ancona
2Pediatria di famiglia, Regione Marche

Indirizzo per corrispondenza: debenedictis@ospedaliriuniti.marche.it

Corticosteroids in respiratory diseases: certainties and doubts

Key words: Corticosteroids, Anti-inflammatory drugs, Meccanism of action, Inhaled route, Adverse effects, Respiratory diseases

Corticosteroids are anti-inflammatory drugs which are used in many pulmonary conditions, either systemically or by inhalation. Corticosteroids have a proven beneficial role in asthma, croup, allergic bronchopulmonary aspergillosis and subglottic hemangioma. In some conditions, such as bronchiolitis, cystic fibrosis and bronchopulmonary dysplasia, their use is controversial and is not recommended routinely. In other conditions, such as tuberculosis, interstitial lung disease, acute lung aspiration and acute respiratory distress syndrome, corticosteroids are often used empirically despite the lack of clear evidence in their favour. There is obvious concern about adverse effects, especially growth and adrenal suppression, induced by systemic corticosteroids in children. These effects have been reduced, but not eliminated with the use of the inhaled route. Physicians should always weigh the benefits against the potential detrimental effects of corticosteroids and the available protocols should be strictly followed in clinical practice.

Vuoi citare questo contributo?

F.M. de Benedictis, F. Franceschini, R. Budassi, A. Capolongo, C. Gobbi, A. Guerrieri, C. Migliori, A. Nobilini, C. Pasqualini I corticosteroidi nelle malattie respiratorie: certezze e dubbi 60 anni dopo (Seconda parte). Medico e Bambino 2012;31(10):652 https://www.medicoebambino.com/?id=1210_652.pdf


L'accesso è riservato agli abbonati alla rivista che si siano registrati.
Per accedere all'articolo in formato full text è necessario inserire nella casella di login username e password.

L'immissione di nuovi contenuti è riservata ai soli utenti registrati