Dicembre 2011 - Volume XXX - numero 10

Medico e Bambino


Problemi speciali

Il deficit di glucosio-6-fosfato deidrogenasi

Matteo Bramuzzo1, Sara Lega1, Irene Bruno2

1Scuola di Specializzazione in Pediatria, Università di Trieste
2Malattie Metaboliche e Rare, Clinica Pediatrica, IRCCS Pediatrico “Burlo Garofolo”, Trieste

Indirizzo per corrispondenza: bramuzzo@tiscalinet.it

GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY

Key words: G6PD deficiency, Favism, Haemolytic anaemia, Oxidative agents, Screening

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked inherited disorder and it is the most common enzymatic defect in the world. G6PD is an enzyme involved in the genesis of NADPH which preserves the cells from oxidative stress. G6PD deficiency is usually asymptomatic but can become clinically apparent as haemolytic crisis triggered by the ingestion of oxidative agents (foods or drugs) or infections. Neonatal jaundice or chronic non-spherocytic haemolytic anaemia may be other manifestations of the disease. The most effective management of G6PD deficiency is to prevent haemolysis by avoiding oxidative stress; blood transfusions may be required in case of severe haemolysis. Screening programmes are helpful in identifying susceptible patients and so in preventing severe haemolytic crisis.

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M. Bramuzzo, S. Lega, I. Bruno Il deficit di glucosio-6-fosfato deidrogenasi. Medico e Bambino 2011;30(10):648-652 https://www.medicoebambino.com/?id=1110_648.pdf


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