Giugno 2009 - Volume XXVIII - numero 6

Medico e Bambino


Utilizzo delle immunoglobuline endovenose nella pratica clinica in pediatria

Giovanna Ventura1, Marco Rabusin2, Elena Spinelli3, Raffaele Badolato3

1Clinica Pediatrica, Università di Trieste; 2Unità Operativa di Emato-Oncologia, IRCCS “Burlo Garofolo”, Trieste
3Clinica Pediatrica, Università di Brescia

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Key words: Intravenous immunoglobuline, Children, Therapy

Intravenous immunoglobuline is a blood product prepared from the serum of between 1,000 and 15,000 donors per batch. It is the treatment indicated for patients with antibody deficiencies and it is used in replacement doses of 200-400 mg/kg. In contrast, high IVIg doses generally given at 2 g/kg are used as immunomodulatory agent in an increasing number of immune and inflammatory disorders such as: immune thrombocytopenic purpura, Kawasaki syndrome, dermatomyositis, toxic epidermal necrolysis, autoimmune neurological diseases as Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy, and post bone marrow transplantation. In the paper the Authors review recent development in the understanding of the mechanism of action of IVIg, the major current clinical applications and the most common side effects.

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G. Ventura, M. Rabusin, E. Spinelli, R. Badolato
Utilizzo delle immunoglobuline endovenose nella pratica clinica in pediatria
Medico e Bambino 2009;28(6):371-381

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