Dicembre 2006 - Volume XXV - numero 10

Medico e Bambino


Articolo speciale

Il danno cerebrale minimo, ovvero il disturbo maturativo dell'encefalo

FRANCO PANIZON

Professore Emerito, Dipartimento di Scienze della Riproduzione e dello Sviluppo, Università di Trieste

MINIMAL BRAIN DAMAGE AND CEREBRAL INTRAUTERINE DEVELOPMENT: AN OVERVIEW OF THE LITERATURE

Key words: Minimal brain damage, Prematurity, Neurological development, Risk factors, Review

The fetal period is a very sensitive epoch in human brain development, as any traumatic event may result in a permanent damage. A preterm birth is usually followed by a slowing down in growth, defined as post-natal malnutrition. This may lead to a reduced head circumference, which is the strongest predictor of suboptimal neurodevelopment in the long-term. In comparison to at term infants, the prematurely born may experience reduced IQ, learning difficulties and attention deficit disorders. Post-natal malnutrition may represent a generalisable model of neurological damage. Some of the external causes of the latter have been identified and include maternal smoking, heavy alcohol consumption, psycho-social stress in the mother, environmental polluting agents. All these factors may interact with genetic variants. Post-natal nutrition interventions may be of value in ameliorating neurological developmental problems in premature babies.

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F. Panizon Il danno cerebrale minimo, ovvero il disturbo maturativo dell'encefalo. Medico e Bambino 2006;25(10):647-655 https://www.medicoebambino.com/?id=0610_647.pdf


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