Luglio 2004 - Volume XXIII - numero 7
Pagine elettroniche
1Servizio Epidemiologico
2Servizio Farmaceutico
3UO Pediatria
4Pediatra di libera scelta
5Direzione Generale ULSS 4
6Coordinamento Distretti Sanitari,
7Istituto di Igiene dell’Università di Padova
Key words: Antibiotics, Prescription, Paediatrics
Prescriptions of antibiotics to children aged 0 to 14 and belonging to the Health Unit “Alto Vicentino” were analysed for the year 2002. 41% of children received at least one prescription. 20% of prescriptions were made by physicians who where not the family doctor usually in charge of the child. Multivariate analysis showed that the determinants of antibiotic prescription were age and nationality of the child, the sex of the doctor (males prescribed significantly more antibiotics than female doctors) and the total number of children whom the physician was in charge of (the greater the number of the patients, the lower the chance of prescription). Amoxycillin was the most used antibiotic in children younger than two years, while amoxi-clavulanic and cefalosporins were the most frequently used in the period of maximum prescription, i.e. from 2 to 6 years.
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Pagine elettroniche
UO di Pediatria, Ospedale “M. Bufalini”, Cesena
*Dipartimento di Pediatria, Università di Brescia
Key words: X-linked thrombocytopenia, WASP gene, Phenotypes
Wiskott-Aldrich (WAS) and X-linked thrombocytopenia (XLT) are two disorders caused by different mutations of the gene WASP. WAS is characterized by recurrent infections, eczema, thrombocytopenia with low mean platet volume (MPV) and increased susceptibility to autoimmune disease and malignancies, while in XLT the phenotype is milder: eczema, if present, is mild, and the immune functions are generally normal and no major episodes of bleeding are described. This spectrum of phenotypes associated with abnormalities of the WASP gene reflects the heterogeneity of the mutations.
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