Maggio 2004 - Volume XXIII - numero 5
Pagine elettroniche
1Servizio di Epidemiologia, AUSL 3, Catania
2Scuola di Specializzazione Igiene e Medicina Preventiva, Università di Catania
Key words: Pertussis, Outbreak, Vaccination
In the year 2002 a pertussis outbreak was reported in the province of Catania. The sources on incident cases were pertussis notification and number of hospitalisation extracted from administrative database. Seventy-two cases of pertussis in patients with median age of 11 months were reported. Pertussis affected predominantly infants (N=52) who were not immunized and with family contact with index of suspicion for pertussis. It appears that heard immunity does not offer adequate protection to the vulnerable group even in well-vaccinated populations. High vaccination coverage should be maintained and vaccination should be given as early an age as possible. The potential benefits of booster vaccination in adolescent and adults could be taken into the account.
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Pagine elettroniche
Dipartimento di Scienze Pediatriche e dell’Adolescenza - Reparto Lattanti, Ospedale Infantile Regina Margherita, Torino
Key words: Acute pyelonephritis, Antibiotic resistance
Acute pyelonephritis (APN) involves a risk of irreversible renal injury. There is no consensus on which therapy is most effective. In this study, we evaluated 108 infants aged 0-18 months, enrolled from 1/5/98 to 31/1/03, for APN. 35 patients (37%) had vesicoureteral reflux (VUR). The etiological agent was Escherichia coli in 94% of cases. Of all antibiotic tested, E. coli was sensitive to amoxicillin in 71% of cases, to amoxicillin-clavulanic acid in 79%, to cefaclor in 78%, to cefpodoxime in 100%, to ceftazidime in 100%, to cotrimoxazole in 82%, to ciprofloxacin in 97%, to ceftriaxone in 99%, to gentamycin in 100%, to nitrofurantoin in 100%. Third generation cephalosporin and aminoglycoside are first line antibiotics for APN, while resistance to amoxicillin-clavulanic acid are increasing (21% of cases). Treatment of APN must be chosen on the basis of local antibiotic resistance patterns.
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Pagine elettroniche
UO Pediatria, *UO Dermatologia, Ospedale di Lucca
Key words: Convulsions, Connective tissue disorders, Hair abnormalities, Menkes disease
The Authors described a case of a newborn affected by Menkes disease (MNK) with convulsions, connective tissue disorders and hair abnormalities. MNK is an X-linked recessive disorder characterised by a copper-transporting ATPase defect. Subcutaneous injections of copper-histidine complex, which currently forms the accepted mode of treatment, prevent the neurological degeneration in some patients when the treatment is initiated soon after birth. However, when the treatment is started later, the neurological degenerative processes are not prevented. Moreover, the treatment does not improve the connective tissue disorders.
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