Dipartimento di Pediatria, Divisione di Gastroenterologia Pediatrica, Children's Hospital di Pittsburgh (Pennsylvania, USA)
CHRONIC INTESTINAL PSEUDO-OBSTRUCTION
Key words: Pseudo-obstruction, Gastrointestinal motor disorders, Enteric neuromuscular diseases
Chronic intestinal pseudo-obstruction is a rare disabling disorder characterized by recurrent
or continuous symptoms and signs of bowel obstruction in the absence of lumen-blocking lesions.
The presenting symptoms depend on the regions of the gastrointestinal tract involved, with
the small intestine involved almost invariably but with no pathognomonic sign or symptom. There
is no single laboratory test that will diagnose pseudo-obstruction: the two most important elements
are suspecting the diagnosis and excluding a mechanical obstruction. The most beneficial
interventions in patients with pseudo-obstruction are the bowel decompression through
the venting ostomies and an effective nutritional support. Therapeutic options also include
prokinetic drugs with small bowel transplantation presently being the only definitive cure for
patients with pseudo-obstruction.