Marzo 2002 - Volume XXI - numero 3

Medico e Bambino


Aggiornamento monografico

Lectina legante il mannosio e suscettibilità alle infezioni

FABIO CARDINALE1, ANNA CALÒ1, RAFFAELLA CAVALLONE1, ELIO COSTANTINO2, MARIA S. LOFFREDO1, GAIA IACOVIELLO1, LUCIO ARMENIO1

1Clinica Pediatrica III, Sezione di Immunoallergologia e Broncopneumologia Pediatrica, Dipartimento di Biomedicina dell’Età Evolutiva, Università di Bari;
2Divisione di Pneumologia, AO Policlinico di Bari

MANNOSE-BINDING LECTIN AND SUSCEPTIBILITY TO INFECTIONS

Key words: Mannose-binding lectin, Complement, Cystic fibrosis, Innate immunity, Opsonisation, Meningococcal disease

Mannose-binding lectin (MBL) is an acute phase protein, belonging to the collectins family, involved in host innate immunity. It binds to surface mannose-rich glycoproteins of several microorganisms, inducing phagocytosis by opsonic and complement activating properties. Both heterozygous and homozygous carriers of MBL-gene variant alleles seem more susceptible to some infections. However, low serum MBL levels are not likely the only cause of clinical illness. More probably an overt clinical pathology occurrs when an MBL-deficient status associates with some other immune defect or disease. Recent studies have shown an association between MBL-gene variant alleles and meningococcal-disease susceptibility. In addition, a low-producing MBL gene phenotype seems to be associated with a poor prognosis in cystic fibrosis. Some evidence also exists about a role of MBL in some autoimmune diseases.

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F. Cardinale, A. Calo, R. Cavallone, et al. Lectina legante il mannosio e suscettibilità alle infezioni. Medico e Bambino 2002;21(3):155-160 https://www.medicoebambino.com/?id=0203_155.pdf


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