Giugno 2000 - Volume XIX - numero 6

Medico e Bambino

Farmacologia clinica

Un farmaco, una malattia: il methotrexate nell’artrite giovanile


Clinica Pediatrica, IRCCS “Burlo Garofolo”, Trieste


Key words: Idiopathic juvenile arthritis, methotrexate

In 1992 a pioneer collaborative study showed that methotrexate (M) is effective in paediatric reumatology. Now we know that 60% of IJA patients who do not respond to non-steroidal antinflammatory drugs respond to M, that the best response is observed in pauciarticular forms evolving in poliarticular as well as in poliarticular forms at onset. Side effects are mainly gastroenteric, but they rarely cause withdrawal of treatment. No gonadal damage and no increased risk of cancer have been observed. The administration of folinic acid reduces the likelihood of side effects. Oral M is as effective as intramuscular M. M should be considered the first choice long-acting drug for all forms of IJA.

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L. Lepore Un farmaco, una malattia: il methotrexate nell’artrite giovanile. Medico e Bambino 2000;19(6):361-363

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