M&B Pagine Elettroniche
Il punto su
Glomerulopatia da depositi di C3
1Università di Trieste
2IRCCS Materno-Infantile “Burlo Garofolo”, Trieste
Indirizzo per corrispondenza: stefanoamoroso1234@gmail.com
C3-glomerulopathy - What should paediatricians know
Key words: C3-glomerulopathy, Hypocomplementemia, Membranoproliferative glomerulonephritis, Mofetil micofenolate, Eculizumab
C3-glomerulopathy includes several nephropathy charac-terised by almost only C3 deposits without immunoglobu-lins with a mesangial proliferative or membrano-proliferative pattern on light microscopy. C3-glomerulopathy is determined by a dysregulation of the al-ternative pattern of complement due to autoantibodies such as C3 nephritic factor or mutations of complement pro-teins. Corticosteroids combined with mofetil micofenolate could be effective in inducing a partial or complete remis-sion. Eculizumab, the humanised monoclonal antibody di-rected against C5, has been shown to have a favourable effect in several case series of patients.
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