Encefalite da Herpes virus in una lattante
1Scuola di Specializzazione in Pediatria, UniversitÓ di Ferrara
2UOC di Pediatria e Neonatologia, Ospedale di Ravenna; 3UOC di Pediatria e Terapia Intensiva Pediatrica-Neonatale, Ospedale di Cesena; 4SSD di Neuroradiologia, Ospedale di Ravenna
AUSL della Romagna
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Herpes virus encephalitis in an infant: a case report
Herpes virus, Encephalitis, Diagnosis, Treatment, Case report
The paper presents the case of an infant with HSV-1 herpetic encephalitis. The clinical symptomatology, after contact with the virus and the development of typical vesicular lesions, is characterized by involvement of the central nervous system, with fever, alteration of the state of consciousness, sudden epileptic seizures and initially difficult pharmacological control. The diagnosis was presumed on the basis of the clinic and above all of the images of brain MRI and confirmed by rachicentesis and PCR positivity for HSV-1 DNA. The therapy started approximately 36 hours after the onset of neurological symptoms with aciclovir intravenously and continued for 21 days. The therapy was suspended on the basis of the negativity of HSV in liquor. The reappearance of epileptic seizures has imposed the exclusion of an anti-NMDA-R encephalitis. The neurological outcome is currently severe.
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