Ottobre 2018 - Volume XXXVII - numero 8
Pagine elettroniche
1Università di Trieste
2IRCCS Materno-Infantile “Burlo Garofolo”, Trieste
Indirizzo per corrispondenza: michelapandu@gmail.com
Key words: Coeliac disease, EMA-biopsy test, Anti-transglutaminase IgA deposits
The anti-transglutaminase IgA deposits in the intestinal mucosa, detected by a double-sided direct immunofluorescence (IFD) technique, are the best diagnostic marker for coeliac disease. However, this test is time consuming and largely operator-dependent. This study compared the sensibility and specificity of IgA deposits IFD-test with a new simpler test (EMA-biopsy test), based on the search of the EMA and anti-tTG antibodies in the supernatant of an intestinal mucosa fragment. One hundred thirty-four patients undergoing intestinal biopsy for suspected coeliac disease or for other conditions entered the study. The IFD and EMA-biopsy test showed a comparable, absolute sensibility and specificity for the diagnosis of coeliac disease both in clinically overt cases and in latent ones. EMA-biopsy test may by considered a very useful, simple test for diagnosing or excluding coeliac disease, especially when the clinical, serological and histological picture is not decisive.
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Pagine elettroniche
1Scuola di Specializzazione di Pediatria, Università di Messina
2Scuola di Specializzazione di Pediatria, Università della Campania “Luigi Vanvitelli”, Napoli
3Neuropsichiatria Infantile; 4Clinica Pediatrica, IRCCS Materno-Infantile “Burlo Garofolo”, Trieste
5Università di Trieste
Indirizzo per corrispondenza: epinta@hotmail.com
Key words: Varicella, Neurological complication, Cerebellitis, Ataxia
Acute cerebellitis is the most common neurological complication of varicella and is usually characterised by a benign course and spontaneous resolution within a few days. The paper reports a case in which the ataxia presented a more lasting course than the usual one and complicated by alteration of the vigilance, a clinical picture that might be confused with other neurological complications of varicella in differential diagnosis.
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