UOC di Pediatria e Neonatologia, Ospedale di Ravenna, AUSL della Romagna
*Università di Trieste
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Key words: Dermatomyositis, Autoimmune disease, Anti-PM/Scl antibodies, Overlap syndrome, Hypomyopathic dermatomyositis
Dermatomyositis is a rare autoimmune disease that first affects the proximal muscles of the limbs and skin. The paper describes two cases of dermatomyositis with non-classic symptoms. In the first case the clinical aspects and the positivity for anti-PM/Scl antibodies suggest a diagnosis of overlap syndrome, commonly defined as mixed connectivitis. The second case, instead, regards a hypomyopathic dermatomyositis, a rare condition presenting only with the cutaneous damage and not the muscular one. Some remarkable aspects of the diagnosis and treatment of classic dermatomyositis with its possible variants are summarised.
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