Stevens-Johnson syndrome (SJS) and toxic epidermal
necrolysis (TEN) are 2 rare (1-2 cases per million population
per year) but life-threatening mucocutaneous reactions characterized
by detachment of epidermis, acute skin blisters, and mucous
membrane erosions. Both SJS and TEN represent a spectrum
of a single disease process. Several drugs are highly suspected
to cause SJS/TEN. Non-medication factors have also
been reported to increase the risk of SJS/TEN: many viruses or
bacteria can be trigger agents; many authors have documented
that the majority of cases are related to Mycoplasma pneumoniae
(MP). The article reports the case of a boy hospitalized for
SJS/TEN-overlap triggered by MP pneumonia, which supports
the evidence by other Authors that both SJS and TEN can be
considered infection driven disorders. Documented cases of recurring
SJS/TEN during re-infection with MP have not been
found in current literature. So, this option should be included
when treating children with MP infection.
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