Febbraio 2011 - Volume XXX - numero 2

Medico e Bambino


Pillole: per capire

Dermatite e IgE alte

Raffaele Badolato

Clinica Pediatrica, Università di Brescia

Indirizzo per corrispondenza: badolato@med.unibs.it

DERMATITIS AND HYPER IgE SYNDROME

Key words: Dermatitis, Hyper IgE syndrome, Job Syndrome

A case of Job syndrome is presented. Job syndrome is linked to a dominant autosomal disorder of the gene that codifies an intracellular protein whose function is the transduction of receptorial signals from the membrane to the nucleus. This central disorder explains the diversity and the complexity (resistance defect against staphylococcus, skeletal or facial alterations, IgE hyper production) of the syndrome in relation to other genetic disorders affecting only the immune system or only the mesenchyme. The first manifestation is a resistant dermatitis, with neonatal onset, while infections (staphylococcal, with pneumatoceles and cold granulomas), skeletal disorders (scoliosis and others) and hypereosinophilia with high IgE levels appear later.

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R. Badolato Dermatite e IgE alte. Medico e Bambino 2011;30(2):107 https://www.medicoebambino.com/?id=1102_107.pdf


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