Prevalenza di malattia celiaca in bambini con deficit totale di IgA non identificati dagli IgG e riconosciuta dal test ELISA per anti-htTG
A. Lenhardt, A. Plebani*, A Insalaco*, A. Rovelli*, A. Tommasini, V. Villanacci*, A. Ventura
Dipartimento di Scienze dello Sviluppo. Clinica Pediatrica, IRCCS “Burlo Garofolo”, Università di Trieste; *Dipartimento di Pediatria e Patologia, Università di Brescia
INCIDENCE OF COELIAC DISEASE IN CHILDREN WITH TOTAL IgA DEFICIENCY UNRECOGNISED BY AGA IgGs AND SUCCESSFULLY DIAGNOSED BY AN ANTI-htTG ELISA IgG TEST
Key words: Coeliac disease, IgA deficiency, htTG
The serum of 134 subjects with IgA deficiency was studied
by carrying out an ELISA IgG test for anti-htTG antibodies and
an AGA IgG test. The ELISA test was positive in 16 cases out of
134: AGA IgG test was positive in 22 cases out of 134. Out of the
16 ELISA positive cases, 10 were also positive to intestinal biopsy.
Out of the 22 AGA IgG positive cases, only 2 were also positive to
intestinal biopsy. Than the ELISA IgG test for anti-htTG antibodies
showed a much higher sensitivity and specificity than the AGA IgG
test, and the incidence of coeliac disease in IgA-deficient subjects
could be assessed to 7.4%.