CHRONIC SEVERE MULTI-DRUG RESISTANT THROMBOCYTOPENIA IN A GIRL WITH LYMPHOPROLIFERATIVE AUTOIMMUNE SYNDROME (ALPS). EFFICACY OF CYCLOPHOSPHAMIDE

Key words: ALPS, Canale-Schmidt syndrome, Apoptosis, Thrombocytopenia, Cyclophosphamide

Report of a very severe case of thrombocytopenia with lymphoproliferative autoimmune syndrome (hereditary ALPS) resistant to classical treatments, both in high doses or bolus, with prompt and durable response to cyclophosfamide.