U.O. di Gastroenterologia, Dipartimento di Scienze Pediatriche e dell’Adolescenza, OIRM - S. Anna, Torino;1Laboratorio di Analisi Cliniche
2Divisione di Gastroenterologia, Ospedale Mauriziano, Torino
Key words: Crohn disease (CD), Ulcerative recto-colitis (URC), Anti-Saccharomyces antibodies (ASCA)
We studied the serum of 28 children with IBD (15 URC, 13 CD). ASCAs were always negative in URC and positive in 7/13 CD (localisation: ileocecum and ascending colon). No correlation between ASCA-positivity, age and CD degree of activity was found. ASCAs are specific for CD diagnosis, but their sensitiveness is not sufficient for clinical screening.
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