Marzo 2016 - Volume XXXV - numero 3

Medico e Bambino


Focus

I depositi intestinali degli anticorpi anti-transglutaminasi

Luigina De Leo1, Ilma Korponai-Szabo2, Markku Mäki3, Grazia Di Leo1, Stefano Martelossi1, Vincenzo Villanacci4, Tarcisio Not1,5, Alessandro Ventura1,5

1Clinica Pediatrica, IRCCS Materno-Infantile “Burlo Garofolo”, Trieste
2Department of Paediatrics, University of Debrecen Medical School, Hungary
3Tampere Centre for Child Health Research, School of Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
4Anatomia Patologica, Spedali Civili, Brescia
5Università di Trieste

Indirizzo per corrispondenza: deleo.luigina@libero.it

Intestinal deposits of anti-transglutaminase antibodies

Key words: Coeliac disease, Intestinal deposits of IgA anti-transglutaminase

The serum anti-transglutaminase antibodies are the immunological markers for coeliac disease diagnosis. These autoantibodies are synthesized by B-lymphocytes at the intestinal level and their presence in the form of intestinal deposits is a constant feature in the different clinical entities in which coeliac disease is classified: classical, silent, and potential. These intestinal autoantibodies are the first gluten dependent inflammatory markers and they appear before both the intestinal damage and the serum anti-transglutaminase antibodies. The anti-transglutaminase deposits should be looked for to confirm or exclude the diagnosis of coeliac disease when the clinical and immunological features are incomplete or in asymptomatic at risk patients.

Vuoi citare questo contributo?

L. De Leo, I. Korponai-Szabo, M. Mäki, G. Di Leo, S. Martelossi, V. Villanacci, T. Not, A. Ventura
I depositi intestinali degli anticorpi anti-transglutaminasi
Medico e Bambino 2016;35(3):159-176 https://www.medicoebambino.com/?id=1603_159.pdf


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